Thursday, October 15th
Hall A Hall B
08:45-09:00 Welcome Coffee
09:00-12:00 IACH 1: Transplant Workshop
Moderators: Mohamad Mohty (France); Arnon Nagler (Israel); Bipin Savani (USA)
Part 1
09:00-09:25 Pathophysiology of chronic GVHD: the most recent data:
TBA
09:25-09:55 Modern therapy of chronic GVHD:
Mohamad Mohty (France)
09:55-10:20 Supportive care in chronic GVHD:
Zinaida Perić (Croatia)
10:20-10:45 Coffee break
Part 2
10:45-11:15 Modern approach to conditioning regimens:
TBA
11:15-11:30 A hard case of chronic GVHD:
Yishan Ye (China)
11:30-12:00 Panel discussion: All session faculty
12:00-12:30 IACH 2: Awards Session
Moderators: Mohamad Mohty (France); Arnon Nagler (Israel); Bipin Savani (USA)
12:30-13:00 Lunch Break
13:00-14:15 CLL in the Clinic: Case-Based Decisions From First Line to Relapse
Industry-Supported Symposium
14:15-15:30 Transplant 1: Advances in Allogeneic Transplantation 14:15-15:30 COMydAL 1: MDS I
Moderators: Arnon Nagler (Israel); Annalisa Ruggeri (Italy) Moderators: Matteo Della Porta (Italy); Amy DeZern (USA)
14:15-14:30 Conditioning regimen:
Maud D’Aveni (France)
14:15-14:30 A new MDS classification ahead?
Robert Hasserjian (USA)
14:30-14:45 Revisited TCI:
Alexandros Spyridonidis (Greece)
14:30-14:45 AI in diagnosis and prognostication of MDS and CMML:
Matteo Della Porta (Italy)
14:45-15:00 Graft manipulation and Tregs:
Federico Simonetta (Switzerland)
14:45-15:00 Is there a border between AA and hMDS?
Amy DeZern (USA)
15:00-15:15 Novel combination for GVHD prophylaxis:
Annalisa Ruggeri (Italy)
15:00-15:15 Germline predisposition in MDS, diagnosis and impact on therapy:
Marie Sébert (France)
15:15-15:30 Panel discussion: All session faculty 15:15-15:30 Panel discussion: All session faculty
15:30-16:45 Transplant 2: HCT/CT in Malignancies 15:30-16:45 COMydAL 2: MDS II
Moderators: Eolia Brissot (France); Jaime Sanz Caballer (Spain) Moderators: Lionel Adès (France): Valeria Santini (Italy)
15:30-15:45 Should we transplant TP53 mutated AML?
Xavier Poiré (Belgium)
15:30-15:45 Transplant for MDS in 2026?
David Valcárcel (Spain)
15:45-16:00 CAR-T cells or alloHCT for very high-risk B-ALL in first line:
He Huang (China)
15:45-16:00 Diagnosis and treatment of VEXAS and MDS:
Jérome Hadjadj (France)
16:00-16:15 State-of-the-art CD19 CAR-T cell therapy in DLBCL and future directions:
Roberta di Blasi (France)
16:00-16:15 Therapy of HR MDS: are target drugs the only hope?
Lionel Adès (France)
16:15-16:30 Clinical case 16:15-16:30 Diagnosis and treatment of myeloid neoplasms with tp53 dysfunction:
Matteo Zampini (Italy)
16:30-16:45 Panel discussion: All session faculty 16:30-16:45 Panel discussion: All session faculty
16:45-17:00 Coffee Break
17:00-18:15 Transplant 3: HCT/CT in Non-Malignant Disease 17:00-18:15 COMydAL 3: CMML, MDS/MPN and others
Moderators: Fabio Ciceri (Italy); TBA Moderators: Francesco Onida (Italy); Valeria Santini (Italy)
17:00-17:15 AlloHCT for sickle cell disease?
Erfan Nur (Netherlands)
17:00-17:15 New directions in management of TP53 mutated myeloid neoplasms:
Maximilian Stahl (USA)
17:15-17:30 Gene therapy for sickle cell disease?
Josu de la Fuente (UK)
17:15-17:30 Evolving use of oral HMAs in myeloid malignancies:
Daniel Wiseman (UK)
17:30-17:45 CAR-T cells in autoimmune disease:
Dimitrios Mougiakakos (Germany)
17:30-17:45 Recommendation transplantation in CMML and MDS/MPN:
Francesco Onida (Italy)
17:45-18:00 Gene transfer vs gene editing: efficacy and safety issue:
Fabio Ciceri (Italy)
17:45-18:00 Biology and treatment of CMML:
Mrinal Patnaik (USA)
18:00-18:15 Panel discussion: All session faculty 18:00-18:15 Panel discussion: All session faculty
18:15 Meeting Welcome Reception

IACH track

COMydAL track

COLYM track

MPNCo&D track

Transplant track

Friday, October 16th
Hall A Hall B
08:30-09:45 Transplant 4: Complications 08:30-09:45 COMydAL 4: AML I
Moderators: Iman Abou Dalle (Lebanon); Didier Blaise (France) Moderators: Amer Zeidan (USA) and Tamara Vasilj (Croatia)
08:30-08:45 Endothelial dysfunction: TMA?
Rafael Duarte (Spain)
08:30-08:45 An update on FLT3 inhibitors use in AML:
Christoph Röllig (Germany)
08:45-09:00 Post HCT rehabilitation:
Didier Blaise (France)
08:45-09:00 An update on IDH inhibitors use in AML:
Stéphane De Botton (France)
09:00-09:15 Antibiotic stewardship in alloHCT:
TBA
09:00-09:15 An update on menin inhibitors use in AML:
Amer Zeidan (USA)
09:15-09:30 CNS complications in HCT and CAR-T?
Zinaida Perić (Croatia)
09:15-09:45 Panel discussion: All session faculty
09:30-09:45 Panel discussion: All session faculty
09:45-10:00 Coffee Break
10:00-11:15 Transplant 5: Post HCT Management 10:00-11:15 COMydAL 5: AML II
Moderators: Anne Huynh (France); Bipin Savani (USA) Moderators: Sanam Loghavi (USA); Amer Zeidan (USA)
10:00-10:15 Management of MRD in pre and post alloHCT strategies in AML:
Jaime Sanz Caballer (Spain)
10:00-10:15 How should TP53 mutated myeloid neoplasms be classified?
Coleman Lindsley (USA)
10:15-10:30 Maintenance in AML:
Eolia Brissot (France)
10:15-10:30 Updates on clinical use of MRD for clinical management of AML:
Jacqueline Cloos (Netherlands)
10:30-10:45 DLI:
Raynier Devillier (France)
10:30-10:45 Learnings from HARMONY about genetics determinants of outcomes in AML:
Lars Bullinger (Germany)
10:45-11:00 Nutrition and frailty scale:
María Queralt Salas (Spain)
10:45-11:00 Harmonization efforts of classifications for AML and MDS:
Sanam Loghavi (USA)
11:00-11:15 Panel discussion: All session faculty 11:00-11:15 Panel discussion: All session faculty
11:15-11:30 Technical Break
11:30-11:55 Mechanism of Resistance and Molecular Pathways involved in CLL Progression
Industry-Supported Lecture
11:55-12:05 Break
12:05-12:30 Targeting DLBCL in 2026: From CD20 to Precision Medicine
Industry-Supported Lecture
12:30-13:00 Lunch Break
13:00-14:15 COLYM 1: From Biology to Bedside: What Will Really Change Practice? 13:00-13:05 MPNCo&D opening: Claire Harrison (UK); Ruben Mesa (USA); Naveen Pemmaraju (USA)
13:05-14:15 MPNCo&D 1: Redefining disease and risk: are we stratifying patients correctly?
Moderators: Mehdi Hamadani (USA); Stefano Luminari (Italy) Moderators: Florian Heidel (Germany); Francesca Palandri (Italy)
13:00-13:05 Case report: Persistent CD20 Loss in POD24 Relapsed/Refractory Follicular Lymphoma without Histologic Transformation: A Therapeutic Challenge:
Emília Araújo (Portugal)
13:05-13:20 Patient perspective on MPN priorities for 2026 and beyond:
Werner Zinkand (Germany)
13:05-13:15 Discussion 13:20-13:35 Molecular risk models vs clinical judgement: are mutations driving overtreatment? Should we use them more in ET and PV:
Jean-Jacques Kiladjian (France)
13:15-13:30 Molecular subtyping and functional genomics: what is ready for routine care?
Miguel Angel Piris (Spain)
13:35-13:50 Clonal hematopoiesis vs early MPN: when does ‘watch and wait’ become unsafe?
Adam Mead (UK)
13:30-13:45 ctDNA as a decision-making tool: hype, hope, or hard evidence?
Sven Borchmann (Germany)
13:50-14:05 Symptoms, spleen, survival: which outcome should drive first-line therapy choices in MF?
Claire Harrison (UK)
13:45-14:00 Emerging biomarkers for response prediction to novel agents:
TBA
14:05-14:15 Panel discussion: All session faculty
14:00-14:15 Panel discussion: All session faculty
14:15-15:30 Beyond monotherapy: Unlocking synergy in myelofibrosis treatment
Industry-Supported Symposium
15:30-16:45 COLYM 2: Redefining Frontline Therapy: Risk, Response, and Reality 15:30-16:45 MPNCo&D 2: Anemia in myelofibrosis: mechanism-driven therapy or trial-and-error?
Moderators: Stefano Luminari (Italy); Anna Sureda (Spain) Moderators: Adam Mead (UK); David Ross (Australia)
15:30-15:35 Case report: From Third Relapse to Complete Metabolic Response: Bispecific Antibody Sequencing After Multiple Lines of Therapy in Relapsed/Refractory DLBCL:
Esra Hanedar (Turkey)
15:30-15:45 What causes anemia in MF — cytokines, hepcidin, marrow failure, or treatment effect?
David Ross (Australia)
15:35-15:45 Discussion
15:45-16:00 Biology-driven frontline strategies in aggressive B-cell lymphomas:
Andrew Davies (UK)
15:45-16:00 ESAs, danazol, steroids: obsolete, underused, or still foundational?
Susanne Isfort (Germany)
16:00-16:15 Frontline therapy in high-risk subgroups: elderly fit patients with LBCL:
Farrukh Awan (USA)
16:00-16:15 Novel agents targeting anemia pathways in MF: Searching for the Holy Grail:
Ruben Mesa (USA)
16:15-16:30 Managing primary refractory and early relapsed aggressive B-cell lymphomas: optimizing salvage and bridging strategies:
Rémy Duléry (USA)
16:15-16:35 Anemia as a prognostic marker vs a treatment-limiting toxicity: should it dictate therapy choice?
Yes: Tania Jain (USA)
No: Francesca Palandri (Italy)
16:30-16:45 Panel discussion: All session faculty 16:35-16:45 Panel discussion: All session faculty
16:45-17:00 Coffee Break
17:00-18:15 IACH 3: The BTKi revolution
Moderators: Mohamed Kharfan-Dabaja (USA); Ali Bazarbachi (Lebanon)
17:00-17:25 Chemo-free therapy of relapsed CLL:
Nicolas Stocker (France)
17:25-17:55 Chemo-free therapy of relapsed mantle cell lymphoma:
TBA
17:55-18:15 Panel discussion: All session faculty
Saturday, October 17th
Hall A Hall B
08:30-09:45 COLYM 3: Sequencing in Relapsed Lymphoma: Making Sense of Too Many Options 08:30-09:45 MPNCo&D 3: Next-generation targeted therapies: beyond JAK inhibition in MF
Moderators: Mohamed Kharfan-Dabaja (USA); Anna Sureda (Spain) Moderators: Susanne Isfort (Germany); Andreas Reiter (Germany)
08:30-08:35 Case report: Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue (MALT Lymphoma) Involving the Epididymis and Testis Mimicking Epididymo-Orchitis: A Diagnostic Challenge:
Pina Gálvez Zavala (Spain)
08:30-08:45 Selective pathway targeting (e.g. hepcidin, ACVR1, BCL-2 family, Xpo1, MDM2): real differentiation or incremental gains?
Jennifer O’Sullivan (UK)
08:35-08:45 Discussion
08:45-09:00 Bispecific antibodies vs cellular therapies in FL: how to choose in real-life practice:
Julio Chavez (USA)
08:45-09:00 Early signals from novel agents targeting CALR in MF: how should clinicians interpret phase 1-2 data?
Bethan Psaila (UK)
09:00-09:15 Treatment sequencing in relapsed / refractory MZL: what do we do next?
Côme Bommier (France)
09:00-09:15 Early data on novel JAK inhibitors: molecular markers, phenotype, or treatment history?
John Mascarenhas (USA)
09:15-09:30 Treatment sequencing in relapsed / refractory MCL: what do we do next?
Carlo Visco (Italy)
09:15-09:35 Combination strategies for upfront management: all patients INT-1 or above with splenomegaly and symptoms should receive combination therapy if trials are positive
Yes: Francesco Passamonti (Italy)
No: Florian Heidel (Germany)
09:30-09:45 Panel discussion: All session faculty 09:35-09:45 Panel discussion: All session faculty
09:45-10:00 Coffee Break
10:00-11:15 COLYM 4: Hodgkin Lymphoma: Optimizing Therapy Across Risk Groups 10:00-11:15 MPNCo&D 4: Transplant, disease evolution, and overlap biology
Moderators: Mehdi Hamadani (USA); Anna Sureda (Spain) Moderators: Anna Godfrey (UK); Juan Carlos Hernandez-Boluda (Spain)
10:00-10:05 Case report: Pembrolizumab-Induced Autoimmune Encephalitis in Hodgkin Lymphoma Followed by Successful Autologous Transplantation with Pre-Engraftment Syndrome:
Fanni Borics (Hungary)
10:00-10:15 Who should be referred for transplant today — and who is being missed?
Juan Carlos Hernandez-Boluda (Spain)
10:05-10:15 Discussion
10:15-10:30 Frontline therapy in advanced-stage classical Hodgkin lymphoma: balancing efficacy and toxicity:
Wendy Osborne (UK)
10:15-10:30 Timing allo-HSCT for atypical MPN: earlier, later, or never?
Nicola Polverelli (Italy)
10:30-10:45 PET-adapted and response-adapted strategies: how low can we go?
Andrea Gallamini (Italy)
10:30-10:45 Overlap syndromes (SM-AHN, MPN with eosinophilia): single disease biology or parallel processes?
Andreas Reiter (Germany)
10:45-11:00 Managing relapsed/refractory Hodgkin lymphoma: Checkpoint inhibitors, and beyond:
Graham Collins (UK)
10:45-11:00 Lessons learned from two decades of experience with KIT inhibitors in systemic mastocytosis:
Jason Gotlib (USA)
11:00-11:15 Panel discussion: All session faculty 11:00-11:15 Advanced systemic mastocytosis treatment in 2026: lessons for risk-adapted therapy in MPNs:
Deepti Radia (UK)
11:15-12:30 Essential Thrombocythemia: Contemporary Perspectives on Risk and Therapy
Industry-Supported Symposium
12:30-13:00 Lunch Break
13:00-14:15 COLYM 5: Rare, Neglected, and Difficult Lymphomas 13:00-14:15 MPNCo&D 5: New options for Essential Thrombocythemia and Polycythemia Vera — are they needed and when should we use them?
Moderators: Mohamed Kharfan-Dabaja (USA); Stefano Luminari (Italy) Moderators: Lina Benajiba (France); Claire Woodley (UK)
13:00-13:05 Case report: When the Body Sounds the Alarm First: Tumour Lysis Syndrome as the Initial Presentation of Anaplastic Large Cell Lymphoma – A Case-Based Review with Updated Management:
Marsela Shani (Albania)
13:00-13:15 Interferon — which patients with ET and PV should have it and what is the treatment target?
Lina Benajiba (France)
13:05-13:15 Discussion
13:15-13:30 Peripheral T-cell lymphomas: are we finally improving outcomes?
Eva Domingo-Domènech (Spain)
13:15-13:30 Hepcidin mimetics — how will they be used for PV patients?
Naveen Pemmaraju (USA)
13:30-13:45 Primary CNS and extranodal lymphomas: unmet needs and new strategies:
Kate Cwynarski (UK)
13:30-13:45 Emerging precision therapies in ET:
Anna Godfrey (UK)
13:45-14:00 Management of post-transplant lymphoproliferative disorders (PTLD) and immunodeficiency-associated lymphomas:
Mary Taj (UK)
13:45-14:00 MPN Symptom Burden / Navigating ET and PV from Patient and Caregiver Perspective: Clinical Pearls from the Frontlines:
Claire Woodley (UK)
14:00-14:15 Panel discussion: All session faculty 14:00-14:15 Panel discussion: All session faculty
14:15-15:00 IACH 4: From scientific writing to critical reading
Moderators: Annalisa Ruggeri (Italy); Ali Bazarbachi (Lebanon)
14:15-14:35 Medical writing: should AI step in?
Junia V. Melo (Australia)
14:35-14:55 How to read a research paper:
Mohamad Mohty (France)
14:55-15:00 Discussion
15:00-16:15 IACH 5: Bispecific Antibodies Across the Multiple Myeloma Continuum: From High-Risk Smoldering Myeloma to Relapsed Disease
Moderator: Mohamad Mohty (France)
15:00-15:15 Early Intervention in Multiple Myeloma: Why Move Immunotherapy Earlier?
Salomon Manier (France)
15:15-15:30 Bispecific Antibodies in High-Risk Smoldering myeloma:
Cyrille Touzeau (France)
15:30-15:45 Bispecific Antibodies in late Relapsed/Refractory Myeloma:
Claudio Cerchione (Italy)
15:45-16:00 Toxicity Mitigation, and Practical Implementation:
Mohamad Mohty (France)
16:00-16:15 Panel discussion: All session faculty
16:15-16:30 Coffee Break
16:30-17:00 IACH 6: Keynote Lecture
Moderators: Mohamed Kharfan-Dabaja (USA); Anna Sureda (Spain)
16:30-17:00 Indication for Hematopoietic Cell Transplantation for Hodgkin Lymphoma in 2026:
Ali Bazarbachi (Lebanon)
Thursday, October 15th
Hall A Hall B
08:45–09:00 Welcome Coffee
09:00–12:00 IACH 1: Transplant Workshop Moderators: Mohamad Mohty (France); Arnon Nagler (Israel); Bipin Savani (USA)
Part 1
09:00–09:25 Pathophysiology of chronic GVHD: the most recent data: TBA
09:25–09:55 Modern therapy of chronic GVHD: Mohamad Mohty (France)
09:55–10:20 Supportive care in chronic GVHD: Zinaida Perić (Croatia)
10:20–10:45 Coffee break
Part 2
10:45–11:15 Modern approach to conditioning regimens: TBA
11:15–11:30 A hard case of chronic GVHD: Yishan Ye (China)
11:30–12:00 Panel discussion: All session faculty
12:00–12:30 IACH 2: Awards Session Moderators: Mohamad Mohty (France); Arnon Nagler (Israel); Bipin Savani (USA)
12:30–13:00 Lunch Break
13:00–14:15 Industry Symposium 13:00–14:15 Industry Symposium
14:15–15:30 Transplant 1: Advances in Allogeneic Transplantation Moderators: Arnon Nagler (Israel); Annalisa Ruggeri (Italy) 14:15–15:30 COMydAL 1: MDS I Moderators: Matteo Della Porta (Italy); Amy DeZern (USA)
14:15–14:30 Conditioning regimen: Maud D’Aveni (France) 14:15–14:30 A new MDS classification ahead? Robert Hasserjian (USA)
14:30–14:45 Revisited TCI: Alexandros Spyridonidis (Greece) 14:30–14:45 AI in diagnosis and prognostication of MDS and CMML: Matteo Della Porta (Italy)
14:45–15:00 Graft manipulation and Tregs: Federico Simonetta (Switzerland) 14:45–15:00 Is there a border between AA and hMDS? Amy DeZern (USA)
15:00–15:15 Novel combination for GVHD prophylaxis: Annalisa Ruggeri (Italy) 15:00–15:15 Germline predisposition in MDS, diagnosis and impact on therapy: Marie Sébert (France)
15:15–15:30 Panel discussion: All session faculty 15:15–15:30 Panel discussion: All session faculty
15:30–16:45 Transplant 2: HCT/CT in Malignancies Moderators: Eolia Brissot (France); Jaime Sanz Caballer (Spain) 15:30–16:45 COMydAL 2: MDS II Moderators: Lionel Adès (France): Valeria Santini (Italy)
15:30–15:45 Should we transplant TP53 mutated AML? Xavier Poiré (Belgium) 15:30–15:45 Transplant for MDS in 2026? David Valcárcel (Spain)
15:45–16:00 CAR-T cells or alloHCT for very high-risk B-ALL in first line: He Huang (China) 15:45–16:00 Diagnosis and treatment of VEXAS and MDS: Jérome Hadjadj (France)
16:00–16:15 State-of-the-art CD19 CAR-T cell therapy in DLBCL and future directions: Roberta di Blasi (France) 16:00–16:15 Therapy of HR MDS: are target drugs the only hope? Lionel Adès (France)
16:15–16:30 Clinical case 16:15–16:30 Diagnosis and treatment of myeloid neoplasms with tp53 dysfunction: Matteo Zampini (Italy)
16:30–16:45 Panel discussion: All session faculty 16:30–16:45 Panel discussion: All session faculty
16:45–17:00 Coffee Break
17:00–18:15 Transplant 3: HCT/CT in Non-Malignant Disease Moderators: Fabio Ciceri (Italy); TBA 17:00–18:15 COMydAL 3: CMML, MDS/MPN and others Moderators: Francesco Onida (Italy); Valeria Santini (Italy)
17:00–17:15 AlloHCT for sickle cell disease? Erfan Nur (Netherlands) 17:00–17:15 New directions in management of TP53 mutated myeloid neoplasms: Maximilian Stahl (USA)
17:15–17:30 Gene therapy for sickle cell disease? Josu de la Fuente (UK) 17:15–17:30 Evolving use of oral HMAs in myeloid malignancies: Daniel Wiseman (UK)
17:30–17:45 CAR-T cells in autoimmune disease: Dimitrios Mougiakakos (Germany) 17:30–17:45 Recommendation transplantation in CMML and MDS/MPN: Francesco Onida (Italy)
17:45–18:00 Gene transfer vs gene editing: efficacy and safety issue: Fabio Ciceri (Italy) 17:45–18:00 Biology and treatment of CMML: Mrinal Patnaik (USA)
18:00–18:15 Panel discussion: All session faculty 18:00–18:15 Panel discussion: All session faculty
18:15 Meeting Welcome Reception
Friday, October 16th
Hall A Hall B
08:30–09:45 Transplant 4: Complications Moderators: Iman Abou Dalle (Lebanon); Didier Blaise (France) 08:30–09:45 COMydAL 4: AML I Moderators: Amer Zeidan (USA) and Tamara Vasilj (Croatia)
08:30–08:45 Endothelial dysfunction: TMA? Rafael Duarte (Spain) 08:30–08:45 An update on FLT3 inhibitors use in AML: Christoph Röllig (Germany)
08:45–09:00 Post HCT rehabilitation: Didier Blaise (France) 08:45–09:00 An update on IDH inhibitors use in AML: Stéphane De Botton (France)
09:00–09:15 Antibiotic stewardship in alloHCT: TBA 09:00–09:15 An update on menin inhibitors use in AML: Amer Zeidan (USA)
09:15–09:30 CNS complications in HCT and CAR-T? Zinaida Perić (Croatia) 09:15–09:45 Panel discussion: All session faculty
09:30–09:45 Panel discussion: All session faculty
09:45–10:00 Coffee Break
10:00–11:15 Transplant 5: Post HCT Management Moderators: Anne Huynh (France); Bipin Savani (USA) 10:00–11:15 COMydAL 5: AML II Moderators: Sanam Loghavi (USA); Amer Zeidan (USA)
10:00–10:15 Management of MRD in pre and post alloHCT strategies in AML: Jaime Sanz Caballer (Spain) 10:00–10:15 How should TP53 mutated myeloid neoplasms be classified? Coleman Lindsley (USA)
10:15–10:30 Maintenance in AML: Eolia Brissot (France) 10:15–10:30 Updates on clinical use of MRD for clinical management of AML: Jacqueline Cloos (Netherlands)
10:30–10:45 DLI: Raynier Devillier (France) 10:30–10:45 Learnings from HARMONY about genetics determinants of outcomes in AML: Lars Bullinger (Germany)
10:45–11:00 Nutrition and frailty scale: María Queralt Salas (Spain) 10:45–11:00 Harmonization efforts of classifications for AML and MDS: Sanam Loghavi (USA)
11:00–11:15 Panel discussion: All session faculty 11:00–11:15 Panel discussion: All session faculty
11:15–11:30 Technical Break
11:30–11:55 Mechanism of Resistance and Molecular Pathways involved in CLL Progression Industry-Supported Lecture
11:55–12:05 Break
12:05–12:30 Targeting DLBCL in 2026: From CD20 to Precision Medicine Industry-Supported Lecture
12:30–13:00 Lunch Break
13:00–14:15 COLYM 1: From Biology to Bedside: What Will Really Change Practice? Moderators: Mehdi Hamadani (USA); Stefano Luminari (Italy) 13:00–13:05 MPNCo&D opening: Claire Harrison (UK); Ruben Mesa (USA); Naveen Pemmaraju (USA)
13:00–13:05 Case report: Persistent CD20 Loss in POD24 Relapsed/Refractory Follicular Lymphoma without Histologic Transformation: A Therapeutic Challenge: Emília Araújo (Portugal) 13:05–14:15 MPNCo&D 1: Redefining disease and risk: are we stratifying patients correctly? Moderators: Florian Heidel (Germany); Francesca Palandri (Italy)
13:05–13:15 Discussion 13:05–13:20 Patient perspective on MPN priorities for 2026 and beyond: Werner Zinkand (Germany)
13:15–13:30 Molecular subtyping and functional genomics: what is ready for routine care? Miguel Angel Piris (Spain) 13:20–13:35 Molecular risk models vs clinical judgement: are mutations driving overtreatment? Should we use them more in ET and PV: Jean-Jacques Kiladjian (France)
13:30–13:45 ctDNA as a decision-making tool: hype, hope, or hard evidence? Sven Borchmann (Germany) 13:35–13:50 Clonal hematopoiesis vs early MPN: when does ‘watch and wait’ become unsafe? Adam Mead (UK)
13:45–14:00 Emerging biomarkers for response prediction to novel agents: TBA 13:50–14:05 Symptoms, spleen, survival: which outcome should drive first-line therapy choices in MF? Claire Harrison (UK)
14:00–14:15 Panel discussion: All session faculty 14:05–14:15 Panel discussion: All session faculty
14:15–15:30 Industry Symposium 14:15–15:30 Industry Symposium
15:30–16:45 COLYM 2: Redefining Frontline Therapy: Risk, Response, and Reality Moderators: Stefano Luminari (Italy); Anna Sureda (Spain) 15:30–16:45 MPNCo&D 2: Anemia in myelofibrosis: mechanism-driven therapy or trial-and-error? Moderators: Adam Mead (UK); David Ross (Australia)
15:30–15:35 Case report: From Third Relapse to Complete Metabolic Response: Bispecific Antibody Sequencing After Multiple Lines of Therapy in Relapsed/Refractory DLBCL: Esra Hanedar (Turkey) 15:30–15:45 What causes anemia in MF — cytokines, hepcidin, marrow failure, or treatment effect? David Ross (Australia)
15:35–15:45 Discussion
15:45–16:00 Biology-driven frontline strategies in aggressive B-cell lymphomas: Andrew Davies (UK) 15:45–16:00 ESAs, danazol, steroids: obsolete, underused, or still foundational? Susanne Isfort (Germany)
16:00–16:15 Frontline therapy in high-risk subgroups: elderly fit patients with LBCL: Farrukh Awan (USA) 16:00–16:15 Novel agents targeting anemia pathways in MF: Searching for the Holy Grail: Ruben Mesa (USA)
16:15–16:30 Managing primary refractory and early relapsed aggressive B-cell lymphomas: optimizing salvage and bridging strategies: Rémy Duléry (USA) 16:15–16:35 Anemia as a prognostic marker vs a treatment-limiting toxicity: should it dictate therapy choice? Yes: Tania Jain (USA) No: Francesca Palandri (Italy)
16:30–16:45 Panel discussion: All session faculty 16:35–16:45 Panel discussion: All session faculty
16:45–17:00 Coffee Break
17:00–18:15 IACH 3: The BTKi revolution Moderators: Mohamed Kharfan-Dabaja (USA); Ali Bazarbachi (Lebanon)
17:00–17:25 Chemo-free therapy of relapsed CLL: Nicolas Stocker (France)
17:25–17:55 Chemo-free therapy of relapsed mantle cell lymphoma: TBA
17:55–18:15 Panel discussion: All session faculty
Saturday, October 17th
Hall A Hall B
08:30–09:45 COLYM 3: Sequencing in Relapsed Lymphoma: Making Sense of Too Many Options Moderators: Mohamed Kharfan-Dabaja (USA); Anna Sureda (Spain) 08:30–09:45 MPNCo&D 3: Next-generation targeted therapies: beyond JAK inhibition in MF Moderators: Susanne Isfort (Germany); Andreas Reiter (Germany)
08:30–08:35 Case report: Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue (MALT Lymphoma) Involving the Epididymis and Testis Mimicking Epididymo-Orchitis: A Diagnostic Challenge: Pina Gálvez Zavala (Spain) 08:30–08:45 Selective pathway targeting (e.g. hepcidin, ACVR1, BCL-2 family, Xpo1, MDM2): real differentiation or incremental gains? Jennifer O’Sullivan (UK)
08:35–08:45 Discussion
08:45–09:00 Bispecific antibodies vs cellular therapies in FL: how to choose in real-life practice: Julio Chavez (USA) 08:45–09:00 Early signals from novel agents targeting CALR in MF: how should clinicians interpret phase 1-2 data? Bethan Psaila (UK)
09:00–09:15 Treatment sequencing in relapsed / refractory MZL: what do we do next? Côme Bommier (France) 09:00–09:15 Early data on novel JAK inhibitors: molecular markers, phenotype, or treatment history? John Mascarenhas (USA)
09:15–09:30 Treatment sequencing in relapsed / refractory MCL: what do we do next? Carlo Visco (Italy) 09:15–09:35 Combination strategies for upfront management: all patients INT-1 or above with splenomegaly and symptoms should receive combination therapy if trials are positive Yes: Francesco Passamonti (Italy) No: Florian Heidel (Germany)
09:30–09:45 Panel discussion: All session faculty 09:35–09:45 Panel discussion: All session faculty
09:45–10:00 Coffee Break
10:00–11:15 COLYM 4: Hodgkin Lymphoma: Optimizing Therapy Across Risk Groups Moderators: Mehdi Hamadani (USA); Anna Sureda (Spain) 10:00–11:15 MPNCo&D 4: Transplant, disease evolution, and overlap biology Moderators: Anna Godfrey (UK); Juan Carlos Hernandez-Boluda (Spain)
10:00–10:05 Case report: Pembrolizumab-Induced Autoimmune Encephalitis in Hodgkin Lymphoma Followed by Successful Autologous Transplantation with Pre-Engraftment Syndrome: Fanni Borics (Hungary) 10:00–10:15 Who should be referred for transplant today — and who is being missed? Juan Carlos Hernandez-Boluda (Spain)
10:05–10:15 Discussion
10:15–10:30 Frontline therapy in advanced-stage classical Hodgkin lymphoma: balancing efficacy and toxicity: Wendy Osborne (UK) 10:15–10:30 Timing allo-HSCT for atypical MPN: earlier, later, or never? Nicola Polverelli (Italy)
10:30–10:45 PET-adapted and response-adapted strategies: how low can we go? Andrea Gallamini (Italy) 10:30–10:45 Overlap syndromes (SM-AHN, MPN with eosinophilia): single disease biology or parallel processes? Andreas Reiter (Germany)
10:45–11:00 Managing relapsed/refractory Hodgkin lymphoma: Checkpoint inhibitors, and beyond: Graham Collins (UK) 10:45–11:00 Lessons learned from two decades of experience with KIT inhibitors in systemic mastocytosis: Jason Gotlib (USA)
11:00–11:15 Panel discussion: All session faculty 11:00–11:15 Advanced systemic mastocytosis treatment in 2026: lessons for risk-adapted therapy in MPNs: Deepti Radia (UK)
11:15–12:30 Industry Symposium 11:15–12:30 Industry Symposium
12:30–13:00 Lunch Break
13:00–14:15 COLYM 5: Rare, Neglected, and Difficult Lymphomas Moderators: Mohamed Kharfan-Dabaja (USA); Stefano Luminari (Italy) 13:00–14:15 MPNCo&D 5: New options for Essential Thrombocythemia and Polycythemia Vera — are they needed and when should we use them? Moderators: Lina Benajiba (France); Claire Woodley (UK)
13:00–13:05 Case report: When the Body Sounds the Alarm First: Tumour Lysis Syndrome as the Initial Presentation of Anaplastic Large Cell Lymphoma – A Case-Based Review with Updated Management: Marsela Shani (Albania) 13:00–13:15 Interferon — which patients with ET and PV should have it and what is the treatment target? Lina Benajiba (France)
13:05–13:15 Discussion
13:15–13:30 Peripheral T-cell lymphomas: are we finally improving outcomes? Eva Domingo-Domènech (Spain) 13:15–13:30 Hepcidin mimetics — how will they be used for PV patients? Naveen Pemmaraju (USA)
13:30–13:45 Primary CNS and extranodal lymphomas: unmet needs and new strategies: Kate Cwynarski (UK) 13:30–13:45 Emerging precision therapies in ET: Anna Godfrey (UK)
13:45–14:00 Management of post-transplant lymphoproliferative disorders (PTLD) and immunodeficiency-associated lymphomas: Mary Taj (UK) 13:45–14:00 MPN Symptom Burden / Navigating ET and PV from Patient and Caregiver Perspective: Clinical Pearls from the Frontlines: Claire Woodley (UK)
14:00–14:15 Panel discussion: All session faculty 14:00–14:15 Panel discussion: All session faculty
14:15–15:00 IACH 4: From scientific writing to critical reading Moderators: Annalisa Ruggeri (Italy); Ali Bazarbachi (Lebanon)
14:15–14:35 Medical writing: should AI step in? Junia V. Melo (Australia)
14:35–14:55 How to read a research paper: Mohamad Mohty (France)
14:55–15:00 Discussion
15:00-16:15 IACH 5: Bispecific Antibodies Across the Multiple Myeloma Continuum: From High-Risk Smoldering Myeloma to Relapsed Disease Moderator: Mohamad Mohty (France)
15:00–15:15 Early Intervention in Multiple Myeloma: Why Move Immunotherapy Earlier? Salomon Manier (France)
15:15–15:30 Bispecific Antibodies in High-Risk Smoldering myeloma: Cyrille Touzeau (France)
15:30–15:45 Bispecific Antibodies in late Relapsed/Refractory Myeloma: Claudio Cerchione (Italy)
15:45–16:00 Toxicity Mitigation, and Practical Implementation: Mohamad Mohty (France)
16:00–16:15 Panel discussion: All session faculty
16:15–16:30 Coffee Break
16:30–17:00 IACH 6: Keynote Lecture Moderators: Mohamed Kharfan-Dabaja (USA); Anna Sureda (Spain)
16:30–17:00 Indication for Hematopoietic Cell Transplantation for Hodgkin Lymphoma in 2026: Ali Bazarbachi (Lebanon)