Optimizing Care in Relapsed/Refractory (R/R)
Chronic Lymphocytic Leukemia (CLL):
Practical Approaches to Challenging Decisions

Friday, October 10th 2025
13:40 – 15:10 CEST (UTC +2)
Hall A, Pullman Paris Tour Eiffel, Paris, France

Dr. Anne-Sophie Michallet

Center Léon Bérard,
Lyon, France

CHAIR

Prof. Giorgio Minotti

University Campus
Bio-Medico of Rome
Rome, Italy

Prof. Farrukh Awan

Harold C. Simmons
Comprehensive
Cancer Center,
University of Texas
Southwestern Medical
Center
Texas, USA

Asst. Prof. Maria Dimou

National and Kapodistrian
University of Athens
Athens, Greece

Agenda
13:40–13:45 Welcome and introduction
Chair: Dr. Anne-Sophie Michallet
13:45–14:05 How do BTK inhibitors work and how do they differ from each other?
Prof. Giorgio Minotti
Q&A
14:05–14:15 Sequencing in post-cBTKi CLL: What does the clinical trial data tell us?
Prof. Farrukh Awan
14:15–14:30 Clinical case discussion 1
Prof. Farrukh Awan
14:30–14:40 Sequencing in post-cBTKi CLL: What does the real-world evidence tell us?
Asst. Prof. Maria Dimou
14:40–14:55 Clinical case discussion 2
Asst. Prof. Maria Dimou
14:55–15:05 Panel discussion and Q&A
All speakers
15:05–15:10 Conclusion and closing remarks
Chair: Dr. Anne-Sophie Michallet

BTK: Bruton’s tyrosine kinase; cBTKi: covalent Bruton’s Tyrosine Kinase inhibitor; CEST: Central European Summer Time; CLL: Chronic Lymphocytic Leukemia; IACH: International Academy of Clinical Hematology; R/R: Relapsed Refractory; UTC: Universal Time Coordinated.

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